At the Newcastle University Structural Biology Facility, we are dedicated to advancing the understanding of protein structures by providing researchers with access to state-of-the-art technology and expert assistance. Our platform offers cutting-edge tools to solve complex protein structures, empowering breakthroughs in structural biology .
With our advanced X-ray diffraction system and the upcoming addition of a Cryo-Electron Microscope (Cryo-EM), we are equipped to support a wide range of projects, from crystallography to cryo-EM studies. Whether you are a seasoned structural biologist or new to the field, our team is here to help you at every stage of your research
- Progress Update: August 25, 2025 – First Grid Imaged
The installation of our new cryo-electron microscope at Newcastle University has reached a significant milestone. The system is now fully insulated with SF6 gas, With the microscope powered up, … - Progress Update: Tundra Installation — August 20, 2025
We’re excited to share the latest advances in the Tundra project as of 20 August 2025. The installation is moving swiftly, and here’s how things stand: The wiring had … - The Tundra is being installed!
We are thrilled to announce that our brand-new ThermoFisher Scientific Tundra Cryo-EM has arrived and is now being installed! Over the past few days, ThermoFisher’s engineers have been hard …
X-Ray
X-ray crystallography allows us to determine the three-dimensional atomic structure of proteins by first purifying and crystallizing them. Once we have protein crystals, we expose them to high-intensity X-rays using advanced diffraction equipment. The way these X-rays are diffracted by the atoms in the crystal provides valuable data. We can then analyze to reveal the protein’s precise atomic arrangement. At our facility, we have an in-house Bruker MetalJet X-ray source. It provides cutting-edge capabilities for studying these structures with exceptional detail and clarity.
New Tundra Cryo-EM Microscope Coming to NUSBF!
We are thrilled to announce the arrival of a Thermo Scientific Tundra Cryo-Transmission Electron Microscope (Cryo-TEM).
The new equipment will be installed during August and September, and will be available for use in September. Stay tuned for the opening events!
This efficient and cost-effective instrument will enhance our structural biology capabilities by providing high-contrast imaging at resolutions as fine as 3 Å, allowing in-house reconstruction of some biomolecular structures.
Location
Newcastle University
Structural Biology Facility
Medical School, NUBI
Framlington place
NE2 4HH
Pages
Contact us
+44 (0)191 208 5482