At NUSBF, we are dedicated to advancing the understanding of protein structures by providing researchers with access to state-of-the-art technology and expert assistance. Our platform offers cutting-edge tools to solve complex protein structures, empowering breakthroughs in structural biology and related fields.
With our advanced X-ray diffraction system and the upcoming addition of a Cryo-Electron Microscope (Cryo-EM), we are equipped to support a wide range of projects, from crystallography to cryo-EM studies. Whether you are a seasoned structural biologist or new to the field, our team is here to help you at every stage of your research
X-Ray
X-ray crystallography allows us to determine the three-dimensional atomic structure of proteins by first purifying and crystallizing them. Once we have protein crystals, we expose them to high-intensity X-rays using advanced diffraction equipment. The way these X-rays are diffracted by the atoms in the crystal provides valuable data, which we can then analyze to reveal the protein’s precise atomic arrangement. At our facility, we have an in-house Bruker MetalJet X-ray source, which provides cutting-edge capabilities for studying these structures with exceptional detail and clarity.
New Tundra Cryo-EM Microscope Coming to NUSBF!
We are thrilled to announce the arrival of a Thermo Scientific Tundra Cryo-Transmission Electron Microscope (Cryo-TEM), set to be operational by August 2025. This efficient and cost-effective instrument will enhance our structural biology capabilities by providing high-contrast imaging at resolutions as fine as 3 Å, allowing in-house reconstruction of some biomolecular structures.
Location
Newcastle University
Structural Biology Facility
Medical School, NUBI
Framlington place
NE2 4HH
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Contact us
+44 (0)191 208 5482