At the Newcastle University Structural Biology Facility, we are dedicated to advancing the understanding of protein structures by providing researchers with access to state-of-the-art technology and expert assistance. Our platform offers cutting-edge tools to solve complex protein structures, empowering breakthroughs in structural biology .
With our advanced X-ray diffraction system and the upcoming addition of a Cryo-Electron Microscope (Cryo-EM), we are equipped to support a wide range of projects, from crystallography to cryo-EM studies. Whether you are a seasoned structural biologist or new to the field, our team is here to help you at every stage of your research
- Save the Date: CCP4 Northern Structural Biology Meeting 2026
We are excited to announce that the CCP4 Northern Structural Biology Meeting is returning to Newcastle for 2026! Join us for three days of cutting-edge research, networking, and technical … - Progress Update: August 25, 2025 – First Grid Imaged
The installation of our new cryo-electron microscope at Newcastle University has reached a significant milestone. The system is now fully insulated with SF6 gas, With the microscope powered up, … - Progress Update: Tundra Installation — August 20, 2025
We’re excited to share the latest advances in the Tundra project as of 20 August 2025. The installation is moving swiftly, and here’s how things stand: The wiring had …
X-Ray
X-ray crystallography allows us to determine the three-dimensional atomic structure of proteins by first purifying and crystallizing them. Once we have protein crystals, we expose them to high-intensity X-rays using advanced diffraction equipment. The way these X-rays are diffracted by the atoms in the crystal provides valuable data. We can then analyze to reveal the protein’s precise atomic arrangement. At our facility, we have an in-house Bruker MetalJet X-ray source. It provides cutting-edge capabilities for studying these structures with exceptional detail and clarity.
New Tundra Cryo-EM Microscope Coming to NUSBF!
We are thrilled to announce the arrival of a Thermo Fisher Scientific Tundra Cryo-Transmission Electron Microscope (Cryo-TEM).
The new equipment is now installed available for use.
This efficient and cost-effective instrument will enhance our structural biology capabilities by providing high-contrast imaging at resolutions as fine as 3 Å, allowing in-house reconstruction of some biomolecular structures.
