Welcome to the Newcastle University Structural Biology Facility

At the Newcastle University Structural Biology Facility, we are dedicated to advancing the understanding of protein structures by providing researchers with access to state-of-the-art technology and expert assistance. Our platform offers cutting-edge tools to solve complex protein structures, empowering breakthroughs in structural biology .

Picture of Arnaud Basle Facility manager

Facility Manager

Dr Arnaud Basle

arnaud.basle.ncl.ac.uk

+44 (0)191 208 5482

The CCP4 Northern Structural Biology Meeting 2025 will be taking place once again in Newcastle on the Thursday 6th – Friday 7th November 2025 (Provisional Dates) at the Frederick Douglass Centre, Newcastle upon Tyne, NE4 5TG.
Please visit the website for more information.

X-Ray source

X-Ray

X-ray crystallography allows us to determine the three-dimensional atomic structure of proteins by first purifying and crystallizing them. Once we have protein crystals, we expose them to high-intensity X-rays using advanced diffraction equipment. The way these X-rays are diffracted by the atoms in the crystal provides valuable data. We can then analyze to reveal the protein’s precise atomic arrangement. At our facility, we have an in-house Bruker MetalJet X-ray source. It provides cutting-edge capabilities for studying these structures with exceptional detail and clarity.

New Tundra Cryo-EM Microscope Coming to NUSBF!

We are thrilled to announce the arrival of a Thermo Scientific Tundra Cryo-Transmission Electron Microscope (Cryo-TEM), set to be operational by August 2025. This efficient and cost-effective instrument will enhance our structural biology capabilities by providing high-contrast imaging at resolutions as fine as 3 Å, allowing in-house reconstruction of some biomolecular structures.

CryoEm microscope
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