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, 2025. Rational engineering of a thermostable α-oxoamine synthase biocatalyst expands the substrate scope and synthetic applicability. Commun Chem 8(1):78
, 2024. Molecular principles of the assembly and construction of a carboxysome shell. Sci Adv 10(48):eadr4227
, 2024. Structural requirements for the specific binding of CRABP2 to cyclin D3. Structure 32(12):2450
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, 2024. Dynamic inter-domain transformations mediate the allosteric regulation of human 5, 10-methylenetetrahydrofolate reductase. Nat Commun 15(1):3248
, 2024. Architecture and regulation of filamentous human cystathionine beta-synthase. Nat Commun 15(1):2931
, 2024. A new family of bacterial ribosome hibernation factors. Nature 626(8001):1125-1132
, 2023. The CCP4 suite: integrative software for macromolecular crystallography. Acta Crystallogr D Struct Biol 79(Pt 6):449-461
, 2023. Important Structural Features of Thiolate-Rich Four-Helix Bundles for Cu(I) Uptake and Removal. Inorg Chem 62(17):6617-6628
, 2023. Identification of D-arabinan-degrading enzymes in mycobacteria. Nat Commun 14(1):2233
, 2023. Structural and biochemical characterisation of the N-carbamoyl-β-alanine amidohydrolase from Rhizobium radiobacter MDC 8606. FEBS J 290(23):5566-5580
, 2023. Versatile Chemo-Biocatalytic Cascade Driven by a Thermophilic and Irreversible C-C Bond-Forming α-Oxoamine Synthase. ACS Sustain Chem Eng 11(21):7997-8002
, 2023. Outer membrane utilisomes mediate glycan uptake in gut Bacteroidetes. Nature 618(7965):583-589
, 2023. BtuB TonB-dependent transporters and BtuG surface lipoproteins form stable complexes for vitamin B(12) uptake in gut Bacteroides. Nat Commun 14(1):4714
, 2023. Dual function of OmpM as outer membrane tether and nutrient uptake channel in diderm Firmicutes. Nat Commun 14(1):7152
, 2022. Sulfated glycan recognition by carbohydrate sulfatases of the human gut microbiota. Nat Chem Biol 18(8):841-849
, 2022. Structure and assembly of the S-layer in C. difficile. Nat Commun 13(1):970
, 2022. A comprehensive structural analysis of the ATPase domain of human DNA topoisomerase II beta bound to AMPPNP, ADP, and the bisdioxopiperazine, ICRF193. Structure 30(8):1129-1145.e3
, 2022. Pore dynamics and asymmetric cargo loading in an encapsulin nanocompartment. Sci Adv 8(4):eabj4461
, 2022. Characterization of inositol lipid metabolism in gut-associated Bacteroidetes. Nat Microbiol 7(7):986-1000
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, 2022. CCP4 Cloud for structure determination and project management in macromolecular crystallography. Acta Crystallogr D Struct Biol 78(Pt 9):1079-1089
, 2022. Plant N-glycan breakdown by human gut Bacteroides. Proc Natl Acad Sci U S A 119(39):e2208168119
, 2022. Structural basis for host recognition and superinfection exclusion by bacteriophage T5. Proc Natl Acad Sci U S A 119(42):e2211672119
, 2021. Acquisition of ionic copper by the bacterial outer membrane protein OprC through a novel binding site. PLoS Biol 19(11):e3001446
, 2021. A single sulfatase is required to access colonic mucin by a gut bacterium. Nature 598(7880):332-337
, 2021. Structural Basis for Silicic Acid Uptake by Higher Plants. J Mol Biol 433(21):167226
, 2021. Discriminative SKP2 Interactions with CDK-Cyclin Complexes Support a Cyclin A-Specific Role in p27KIP1 Degradation. J Mol Biol 433(5):166795
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, 2020. Metabolism of multiple glycosaminoglycans by Bacteroides thetaiotaomicron is orchestrated by a versatile core genetic locus. Nat Commun 11(1):646
, 2020. A practical overview of molecular replacement: Clostridioides difficile PilA1, a difficult case study. Acta Crystallogr D Struct Biol 76(Pt 3):261-271
, 2020. The predictive power of data-processing statistics. IUCrJ 7(Pt 2):342-354
, 2020. Structural and functional insights into oligopeptide acquisition by the RagAB transporter from Porphyromonas gingivalis. Nat Microbiol 5(8):1016-1025
, 2020. Prominent members of the human gut microbiota express endo-acting O-glycanases to initiate mucin breakdown. Nat Commun 11(1):4017
, 2020. An evolutionary path to altered cofactor specificity in a metalloenzyme. Nat Commun 11(1):2738
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, 2020. Dissecting the structural and functional roles of a putative metal entry site in encapsulated ferritins. J Biol Chem 295(46):15511-15526
, 2020. Ascertaining the biochemical function of an essential pectin methylesterase in the gut microbe Bacteroides thetaiotaomicron. J Biol Chem 295(52):18625-18637
, 2020. Uptake of monoaromatic hydrocarbons during biodegradation by FadL channel-mediated lateral diffusion. Nat Commun 11(1):6331
, 2019. Author Correction: A surface endogalactanase in Bacteroides thetaiotaomicron confers keystone status for arabinogalactan degradation. Nat Microbiol 4(11):2021-2023
, 2019. Complex N-glycan breakdown by gut Bacteroides involves an extensive enzymatic apparatus encoded by multiple co-regulated genetic loci. Nat Microbiol 4(9):1571-1581
, 2019. Structural and functional analyses of glycoside hydrolase 138 enzymes targeting chain A galacturonic acid in the complex pectin rhamnogalacturonan II. J Biol Chem 294(19):7711-7721
, 2018. Validating and enabling phosphoglycerate dehydrogenase (PHGDH) as a target for fragment-based drug discovery in PHGDH-amplified breast cancer. Oncotarget 9(17):13139-13153
, 2018. Target highlights from the first post-PSI CASP experiment (CASP12, May-August 2016). Proteins 86 Suppl 1(Suppl 1):27-50
, 2018. Crystal structure of NucB, a biofilm-degrading endonuclease. Nucleic Acids Res 46(1):473-484
, 2018. Dietary pectic glycans are degraded by coordinated enzyme pathways in human colonic Bacteroides. Nat Microbiol 3(2):210-219
, 2018. A charge polarization model for the metal-specific activity of superoxide dismutases. Phys Chem Chem Phys 20(4):2363-2372
, 2018. Insight into Metal Removal from Peptides that Sequester Copper for Methane Oxidation. Chemistry 24(18):4515-4518
, 2018. Structural basis for chitin acquisition by marine Vibrio species. Nat Commun 9(1):220
, 2018. Evolutionary Morphing of Tryptophan Synthase: Functional Mechanisms for the Enzymatic Channeling of Indole. J Mol Biol 430(24):5066-5079
, 2018. Unusual Constriction Zones in the Major Porins OmpU and OmpT from Vibrio cholerae. Structure 26(5):708-721.e4
, 2018. Crystal structure of the Acinetobacter baumannii outer membrane protein Omp33. Acta Crystallogr D Struct Biol 74(Pt 9):852-860
, 2018. A surface endogalactanase in Bacteroides thetaiotaomicron confers keystone status for arabinogalactan degradation. Nat Microbiol 3(11):1314-1326
, 2017. A Bacteroidetes locus dedicated to fungal 1,6-β-glucan degradation: Unique substrate conformation drives specificity of the key endo-1,6-β-glucanase. J Biol Chem 292(25):10639-10650
, 2017. Structural basis for nutrient acquisition by dominant members of the human gut microbiota. Nature 541(7637):407-411
, 2017. Corrigendum: Complex pectin metabolism by gut bacteria reveals novel catalytic functions. Nature 548(7669):612
, 2017. Complex pectin metabolism by gut bacteria reveals novel catalytic functions. Nature 544(7648):65-70
, 2017. Visualizing Biological Copper Storage: The Importance of Thiolate-Coordinated Tetranuclear Clusters. Angew Chem Int Ed Engl 56(30):8697-8700
, 2017. How members of the human gut microbiota overcome the sulfation problem posed by glycosaminoglycans. Proc Natl Acad Sci U S A 114(27):7037-7042
, 2017. An evolutionarily distinct family of polysaccharide lyases removes rhamnose capping of complex arabinogalactan proteins. J Biol Chem 292(32):13271-13283
, 2017. Structural basis for maintenance of bacterial outer membrane lipid asymmetry. Nat Microbiol 2(12):1616-1623
, 2017. Structural insights into the enzymatic activity and potential substrate promiscuity of human 3-phosphoglycerate dehydrogenase (PHGDH). Oncotarget 8(61):104478-104491
, 2016. Bacterial cytosolic proteins with a high capacity for Cu(I) that protect against copper toxicity. Sci Rep 6:39065
, 2016. The Mechanism by Which Arabinoxylanases Can Recognize Highly Decorated Xylans. J Biol Chem 291(42):22149-22159
, 2016. Gram-negative trimeric porins have specific LPS binding sites that are essential for porin biogenesis. Proc Natl Acad Sci U S A 113(34):E5034-43
, 2016. Complexity of the Ruminococcus flavefaciens cellulosome reflects an expansion in glycan recognition. Proc Natl Acad Sci U S A 113(26):7136-41
, 2016. Structural basis for Mep2 ammonium transceptor activation by phosphorylation. Nat Commun 7:11337
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, 2016. Structural Insights into Outer Membrane Permeability of Acinetobacter baumannii. Structure 24(2):221-31
, 2016. Some of the most interesting CASP11 targets through the eyes of their authors. Proteins 84 Suppl 1(Suppl Suppl 1):34-50
, 2015. Small-Molecule Transport by CarO, an Abundant Eight-Stranded β-Barrel Outer Membrane Protein from Acinetobacter baumannii. J Mol Biol 427(14):2329-39
, 2015. The GH130 Family of Mannoside Phosphorylases Contains Glycoside Hydrolases That Target β-1,2-Mannosidic Linkages in Candida Mannan. J Biol Chem 290(41):25023-33
, 2015. Glycan complexity dictates microbial resource allocation in the large intestine. Nat Commun 6:7481
, 2015. A four-helix bundle stores copper for methane oxidation. Nature 525(7567):140-3
, 2014. Structure and function of a spectrin-like regulator of bacterial cytokinesis. Nat Commun 5:5421
, 2014. A human mitochondrial poly(A) polymerase mutation reveals the complexities of post-transcriptional mitochondrial gene expression. Hum Mol Genet 23(23):6345-55
, 2014. Evidence that GH115 α-glucuronidase activity, which is required to degrade plant biomass, is dependent on conformational flexibility. J Biol Chem 289(1):53-64
, 2013. Investigating the role of zinc and copper binding motifs of trafficking sites in the cyanobacterium Synechocystis PCC 6803. Biochemistry 52(39):6816-23
, 2013. Crosstalk between Cu(I) and Zn(II) homeostasis via Atx1 and cognate domains. Chem Commun (Camb) 49(73):8000-2
, 2013. Overproduction, purification, crystallization and preliminary X-ray characterization of the C-terminal family 65 carbohydrate-binding module (CBM65B) of endoglucanase Cel5A from Eubacterium cellulosolvens. Acta Crystallogr Sect F Struct Biol Cryst Commun 69(Pt 2):191-4
, 2013. Understanding how noncatalytic carbohydrate binding modules can display specificity for xyloglucan. J Biol Chem 288(7):4799-809
, 2012. The bacterial stressosome: a modular system that has been adapted to control secondary messenger signaling. Structure 20(2):350-63
, 2012. A scissor blade-like closing mechanism implicated in transmembrane signaling in a Bacteroides hybrid two-component system. Proc Natl Acad Sci U S A 109(19):7298-303
, 2012. Variations in methanobactin structure influences copper utilization by methane-oxidizing bacteria. Proc Natl Acad Sci U S A 109(22):8400-4
, 2012. How nature can exploit nonspecific catalytic and carbohydrate binding modules to create enzymatic specificity. Proc Natl Acad Sci U S A 109(51):20889-94
, 2011. A novel, noncatalytic carbohydrate-binding module displays specificity for galactose-containing polysaccharides through calcium-mediated oligomerization. J Biol Chem 286(25):22499-509
, 2011. Copper-binding properties and structures of methanobactins from Methylosinus trichosporium OB3b. Inorg Chem 50(4):1378-91
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, 2009. Structure of the major carrot allergen Dau c 1. Acta Crystallogr D Biol Crystallogr 65(Pt 11):1206-12
, 2009. Crystal structures of YkuI and its complex with second messenger cyclic Di-GMP suggest catalytic mechanism of phosphodiester bond cleavage by EAL domains. J Biol Chem 284(19):13174-84
, 2006. Crystal structure of osmoporin OmpC from E. coli at 2.0 A. J Mol Biol 362(5):933-42
, 2006. Conductance and selectivity fluctuations in D127 mutants of the bacterial porin OmpF. Eur Biophys J 36(1):13-22
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